AustralieFrV1, Main, Exploration, bibRecord, 003274

Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes

Identifieur interne : 003274 ( Main/Exploration ); précédent : 003273; suivant : 003275

Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes

Auteurs : András N. Spaan [France, Pays-Bas] ; Tamara Reyes-Robles [États-Unis] ; Cédric Badiou [France] ; Sylvie Cochet [France] ; Kristina M. Boguslawski [États-Unis] ; Pauline Yoong [États-Unis] ; Christopher J. Day [Australie] ; Carla J. C. De Haas [Pays-Bas] ; Kok P. M. Van Kessel [Pays-Bas] ; François Vandenesch [France] ; Michael P. Jennings [Australie] ; Caroline Le Van Kim [France] ; Yves Colin [France] ; Jos A. G. Van Strijp [Pays-Bas] ; Thomas Henry [France] ; Victor J. Torres [États-Unis]

Source :

Cell host & microbe [ 1931-3128 ] ; 2015.

RBID : PMC:4578157

Descripteurs français

KwdFr :
- Humains, Hémolyse, Interactions hôte-pathogène, Leucocidine (métabolisme), Liaison aux protéines, Récepteurs de surface cellulaire (métabolisme), Staphylococcus aureus (métabolisme), Système Duffy (métabolisme), Érythrocytes ().
MESH :
- métabolisme : Leucocidine, Récepteurs de surface cellulaire, Staphylococcus aureus, Système Duffy.
- Humains, Hémolyse, Interactions hôte-pathogène, Liaison aux protéines, Érythrocytes.

English descriptors

KwdEn :
- Duffy Blood-Group System (metabolism), Erythrocytes (drug effects), Hemolysis, Host-Pathogen Interactions, Humans, Leukocidins (metabolism), Protein Binding, Receptors, Cell Surface (metabolism), Staphylococcus aureus (metabolism).
MESH :
- chemical , metabolism : Duffy Blood-Group System, Leukocidins, Receptors, Cell Surface.
- drug effects : Erythrocytes.
- metabolism : Staphylococcus aureus.
- Hemolysis, Host-Pathogen Interactions, Humans, Protein Binding.

Abstract

SUMMARY

In order for Staphylococcus aureus to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. S. aureus is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the S. aureus hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with DARC polymorphisms, we determined that HlgAB and LukED-mediated lysis directly relates to DARC expression. DARC is required for S. aureus-mediated lysis of human erythrocytes and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support S. aureus growth in a hemoglobin acquisition-dependent manner. These findings elucidate how S. aureus targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578157

DOI: 10.1016/j.chom.2015.08.001
PubMed: 26320997
PubMed Central: 4578157

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Staphylococcus aureus</italic>
 targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes</title>
<author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boguslawski, Kristina M" sort="Boguslawski, Kristina M" uniqKey="Boguslawski K" first="Kristina M." last="Boguslawski">Kristina M. Boguslawski</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoong, Pauline" sort="Yoong, Pauline" uniqKey="Yoong P" first="Pauline" last="Yoong">Pauline Yoong</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J." last="Day">Christopher J. Day</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222</wicri:regionArea>
<wicri:noRegion>Queensland 4222</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J. C." last="De Haas">Carla J. C. De Haas</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P. M." last="Van Kessel">Kok P. M. Van Kessel</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A8">Hospices Civils de Lyon, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P." last="Jennings">Michael P. Jennings</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222</wicri:regionArea>
<wicri:noRegion>Queensland 4222</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A. G." last="Van Strijp">Jos A. G. Van Strijp</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J." last="Torres">Victor J. Torres</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26320997</idno>
<idno type="pmc">4578157</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578157</idno>
<idno type="RBID">PMC:4578157</idno>
<idno type="doi">10.1016/j.chom.2015.08.001</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001E48</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E48</idno>
<idno type="wicri:Area/Pmc/Curation">001D04</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D04</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001240</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001240</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002940</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002940</idno>
<idno type="wicri:Area/PubMed/Curation">002871</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002871</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002871</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002871</idno>
<idno type="wicri:Area/Ncbi/Merge">002999</idno>
<idno type="wicri:Area/Ncbi/Curation">002999</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002999</idno>
<idno type="wicri:Area/Main/Merge">003275</idno>
<idno type="wicri:Area/Main/Curation">003274</idno>
<idno type="wicri:Area/Main/Exploration">003274</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Staphylococcus aureus</italic>
 targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes</title>
<author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boguslawski, Kristina M" sort="Boguslawski, Kristina M" uniqKey="Boguslawski K" first="Kristina M." last="Boguslawski">Kristina M. Boguslawski</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yoong, Pauline" sort="Yoong, Pauline" uniqKey="Yoong P" first="Pauline" last="Yoong">Pauline Yoong</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J." last="Day">Christopher J. Day</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222</wicri:regionArea>
<wicri:noRegion>Queensland 4222</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J. C." last="De Haas">Carla J. C. De Haas</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P. M." last="Van Kessel">Kok P. M. Van Kessel</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A8">Hospices Civils de Lyon, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P." last="Jennings">Michael P. Jennings</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222</wicri:regionArea>
<wicri:noRegion>Queensland 4222</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris</wicri:regionArea>
<wicri:noRegion>75238 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A. G." last="Van Strijp">Jos A. G. Van Strijp</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name>
<affiliation wicri:level="3"><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, Inserm U1111, CNRS UMR 5308, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon</wicri:regionArea>
<wicri:noRegion>69007 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J." last="Torres">Victor J. Torres</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, New York University School of Medicine, 10016 New York</wicri:regionArea>
<wicri:noRegion>10016 New York</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell host & microbe</title>
<idno type="ISSN">1931-3128</idno>
<idno type="eISSN">1934-6069</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Duffy Blood-Group System (metabolism)</term>
<term>Erythrocytes (drug effects)</term>
<term>Hemolysis</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Leukocidins (metabolism)</term>
<term>Protein Binding</term>
<term>Receptors, Cell Surface (metabolism)</term>
<term>Staphylococcus aureus (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Hémolyse</term>
<term>Interactions hôte-pathogène</term>
<term>Leucocidine (métabolisme)</term>
<term>Liaison aux protéines</term>
<term>Récepteurs de surface cellulaire (métabolisme)</term>
<term>Staphylococcus aureus (métabolisme)</term>
<term>Système Duffy (métabolisme)</term>
<term>Érythrocytes ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Duffy Blood-Group System</term>
<term>Leukocidins</term>
<term>Receptors, Cell Surface</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Erythrocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Leucocidine</term>
<term>Récepteurs de surface cellulaire</term>
<term>Staphylococcus aureus</term>
<term>Système Duffy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Hemolysis</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Protein Binding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Hémolyse</term>
<term>Interactions hôte-pathogène</term>
<term>Liaison aux protéines</term>
<term>Érythrocytes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>SUMMARY</title>
<p id="P3">In order for <italic>Staphylococcus aureus</italic>
 to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. <italic>S. aureus</italic>
 is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the <italic>S. aureus</italic>
 hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with <italic>DARC</italic>
 polymorphisms, we determined that HlgAB and LukED-mediated lysis directly relates to DARC expression. DARC is required for <italic>S. aureus</italic>
-mediated lysis of human erythrocytes and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support <italic>S. aureus</italic>
 growth in a hemoglobin acquisition-dependent manner. These findings elucidate how <italic>S. aureus</italic>
 targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
<li>Utrecht (province)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Lyon</li>
<li>Paris</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name>
</region>
<name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name>
<name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name>
<name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name>
<name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name>
<name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name>
<name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name>
<name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name>
<name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name>
<name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name>
<name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name>
<name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name>
<name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name>
<name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name>
<name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name>
</region>
<name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J. C." last="De Haas">Carla J. C. De Haas</name>
<name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P. M." last="Van Kessel">Kok P. M. Van Kessel</name>
<name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A. G." last="Van Strijp">Jos A. G. Van Strijp</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name>
</noRegion>
<name sortKey="Boguslawski, Kristina M" sort="Boguslawski, Kristina M" uniqKey="Boguslawski K" first="Kristina M." last="Boguslawski">Kristina M. Boguslawski</name>
<name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J." last="Torres">Victor J. Torres</name>
<name sortKey="Yoong, Pauline" sort="Yoong, Pauline" uniqKey="Yoong P" first="Pauline" last="Yoong">Pauline Yoong</name>
</country>
<country name="Australie"><noRegion><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J." last="Day">Christopher J. Day</name>
</noRegion>
<name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P." last="Jennings">Michael P. Jennings</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003274 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003274 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4578157
   |texte=   Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26320997" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes

Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.